GLI2 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comGLI2 Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > GLI2(Gene name) > Human

GLI2 (Gene name),

Zinc finger protein GLI2 (Protein name ), GLI2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GLI2(THP);

Protein name:

Zinc finger protein GLI2;

Alternative:

Tax helper protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interaction with ZIC.

Function:

Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Implicated in the transduction of SHH signal.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

1586

Sequence:

50:

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1400:

1450:

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1550:

1586:

LTLPSIPAGI | SNMAVGDMSS | MLTSLAEESK | FLNMMT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P10070

KEGG:

hsa:2736

String:

P10070

Pfam:

PF00096

MIM:

165230

UniGene:

Hs.111867

STRING:

9606.ENSP00000354586

Uniprot:

P10070

FOR

ELISA Kit for Human Zinc finger protein GLI2

Cat.:

E15151h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Zinc finger protein GLI2

Cat.:

E15151m

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Human Zinc finger protein GLI2

Cat.:

E15151c

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Packing:

96T

CLIA Kit for Human Zinc finger protein GLI2

Cat.:

U15151m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Zinc finger protein GLI2

Cat.:

U15151c

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Zinc finger protein GLI2

Cat.:

U15151h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Zinc finger protein GLI2

Cat.:

P15151Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Zinc finger protein GLI2

Cat.:

P15151Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Zinc finger protein GLI2

Protein for Human Zinc finger protein GLI2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome."
Tanimura A. , Dan S. , Yoshida M.
J. Virol.72:3958-3964(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4);FUNCTION;DNA-BINDING;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANTS SER-1156 AND ASN-1306
2.

"A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2."
Roessler E. , Ermilov A.N. , Grange D.K. , Wang A. , Grachtchouk M. , Dlugosz A.A. , Muenke M.
Hum. Mol. Genet.14:2181-2188(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);FUNCTION;INVOLVEMENT IN PHS2
3.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins."
Tanimura A. , Teshima H. , Fujisawa J. , Yoshida M.
J. Virol.67:5375-5382(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-857 (ISOFORMS 1; 2; 3 AND 4)
5.

"The GLI-Kruppel family of human genes."
Ruppert J.M. , Kinzler K.W. , Wong A.J. , Bigner S.H. , Kao F.T. , Law M.L. , Seuanez H.N. , O'Brien S.J. , Vogelstein B.
Mol. Cell. Biol.8:3104-3113(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 456-560 (ISOFORMS 1; 2; 3 AND 4)
6.

"Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features."
Roessler E. , Du Y.-Z. , Mullor J.L. , Casas E. , Allen W.P. , Gillessen-Kaesbach G. , Roeder E.R. , Ming J.E. , Ruiz i Altaba A. , Muenke M.
Proc. Natl. Acad. Sci. U.S.A.100:13424-13429(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HPE9
7.

"Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling."
Varjosalo M. , Bjorklund M. , Cheng F. , Syvanen H. , Kivioja T. , Kilpinen S. , Sun Z. , Kallioniemi O. , Stunnenberg H.G. , He W.W. , Ojala P. , Taipale J.
Cell133:537-548(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-388 AND SER-1011
8.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234 AND SER-236;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway."
Maloverjan A. , Piirsoo M. , Michelson P. , Kogerman P. , Osterlund T.
Exp. Cell Res.316:627-637(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
10.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; SER-234; SER-236 AND SER-242;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy."
Coni S. , Antonucci L. , D'Amico D. , Di Magno L. , Infante P. , De Smaele E. , Giannini G. , Di Marcotullio L. , Screpanti I. , Gulino A. , Canettieri G.
PLoS ONE8:E65718-E65718(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-757
12.

"Novel heterozygous nonsense GLI2 mutations in patients with hypopituitarism and ectopic posterior pituitary lobe without holoprosencephaly."
Franca M.M. , Jorge A.A. , Carvalho L.R. , Costalonga E.F. , Vasques G.A. , Leite C.C. , Mendonca B.B. , Arnhold I.J.
J. Clin. Endocrinol. Metab.95:E384-E391(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT BY HPE9;INVOLVEMENT IN PHS2;VARIANT PHS2 LEU-608
13.

"GLI2 mutations in four Brazilian patients: how wide is the phenotypic spectrum?"
Rahimov F. , Ribeiro L.A. , de Miranda E. , Richieri-Costa A. , Murray J.C.
Am. J. Med. Genet. A140:2571-2576(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HPE9 GLY-479; SER-932; ILE-1444 AND LEU-1554

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